RecruitingNot ApplicableNCT05048251

Individually Targeted Neuromodulation for Contamination-based OCD

Individually Targeted Neuromodulation for Contamination-based Obsessive-compulsive Disorder


Sponsor

Mclean Hospital

Enrollment

50 participants

Start Date

Jul 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Patients with obsessive-compulsive disorder (OCD) experience a wide array of different types of obsessions and compulsions. However, current treatments for OCD employ a "one size fits all" approach and are used for all patients regardless of symptom type. In this project, the investigators propose to investigate whether a novel method of transcranial magnetic stimulation specifically reduces contamination/washing symptoms - one of the most common types of OCD.


Eligibility

Min Age: 18 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study tests a brain stimulation approach called transcranial magnetic stimulation (TMS) — a non-invasive technique that uses magnetic pulses to stimulate specific brain areas — to treat a specific type of OCD focused on contamination fears (e.g., fear of germs, dirt, or illness). **You may be eligible if...** - You are 18–55 years old with a diagnosis of OCD - Your main OCD symptom is contamination-related fears - You score 8 or higher on the contamination subscale of a standard OCD rating scale - You are either not on psychiatric medication, or have been on a stable dose for at least 4 weeks **You may NOT be eligible if...** - Your main OCD symptoms are something other than contamination (e.g., harm, hoarding, symmetry) - You have metal implants in your head or a history of seizures (safety concern for TMS) - You have a recent history of substance abuse or are actively suicidal - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEcTBS

continuous theta burst stimulation

DEVICEiTBS

intermittent theta burst stimulation

DEVICEsham

sham stimulation


Locations(1)

McLean Hospital

Belmont, Massachusetts, United States

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NCT05048251


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