RecruitingNot ApplicableNCT05048251

Individually Targeted Neuromodulation for Contamination-based OCD

Individually Targeted Neuromodulation for Contamination-based Obsessive-compulsive Disorder

Sponsor

Mclean Hospital

Enrollment

50 participants

Start Date

Jul 1, 2022

Study Type

INTERVENTIONAL

Conditions

Obsessive-Compulsive Disorder

Summary

Patients with obsessive-compulsive disorder (OCD) experience a wide array of different types of obsessions and compulsions. However, current treatments for OCD employ a "one size fits all" approach and are used for all patients regardless of symptom type. In this project, the investigators propose to investigate whether a novel method of transcranial magnetic stimulation specifically reduces contamination/washing symptoms - one of the most common types of OCD.

Eligibility

Min Age: 18 YearsMax Age: 55 Years

Inclusion Criteria6

male or female age 18-55 years old
DSM-5 diagnosis of OCD as primary presenting disorder
CONTAM as the predominant symptom dimension (i.e., Dimension 4 (CONTAM symptoms) is the highest score on the Dimensional Yale-Brown Obsessive Compulsive Scale (D-YBOCS); participants with more than one Dimension as highest score will still be eligible as long as Dimension 4 is one of these)
score of ≥ 8 on Dimension 4 of the D-YBOCS
taking no psychiatric medications or on a stable dose of an SSRI, clomipramine, SNRI, or second generation antipsychotic for at least 4 weeks prior to enrollment. Use of PRN benzodiazepines will be permitted as long as the dose/usage has not changed significantly leading up to enrollment. No medication changes will be permitted during the study
have not initiated a new course of exposure and response prevention (ERP) therapy within 4 weeks of enrollment (ongoing ERP will be permitted if initiated more than 8 weeks before enrollment).

Exclusion Criteria8

positive urine drug screen (other than prescribed benzodiazepines)
use of psychiatric medications other than permitted above
substance use disorder in the last 3 months (with the exception of nicotine)
history of schizophrenia, bipolar disorder, autism, Tourette's syndrome (current and past history of depressive, anxiety, and eating disorders permitted as long as OCD is considered the primary disorder)
active suicidal ideation over the week prior to screening (as indicated by answering yes to questions 1 or 2 on the C-SSRS)
history of traumatic brain injury, seizure disorder, neurodegenerative disease, or other organic brain disease
pregnancy or lactating
contraindication to MRI scanning or TMS