RecruitingPhase 2NCT06376734

Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

Transdiagnostic Circuit Mapping of Prefrontal Targets in Accelerated Transcranial Magnetic Stimulation


Sponsor

Brigham and Women's Hospital

Enrollment

180 participants

Start Date

Jan 30, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Participants will receive Transcranial Magnetic Stimulation (TMS) at a random location in the left prefrontal cortex, excluding sites that are potentially unsafe. Extensive behavioral testing will be conducted to determine which behaviors are modulated by stimulating which circuits.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is looking for new brain targets that could make transcranial magnetic stimulation (TMS) — a non-invasive brain stimulation therapy — more effective for people with depression, anxiety, OCD, or schizophrenia. **You may be eligible if...** - You are between 18 and 65 years old - You have a primary diagnosis of major depression, generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD), or schizophrenia - Your symptoms are above a minimum severity threshold on standardized questionnaires - You have been on the same psychiatric medications (or none) for at least 4 weeks - You are proficient enough in English to complete questionnaires and provide consent **You may NOT be eligible if...** - You have a history of seizures or epilepsy - You have metal implants in your head (such as cochlear implants or aneurysm clips) - You have a different primary psychiatric diagnosis not listed above Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETranscranial magnetic stimulation

Accelerated TMS will be provided for 2 days using the same dosing regimen as the FDA-cleared SAINT protocol, ten 9-minute treatments per day.


Locations(2)

Acacia Clinics

Sunnyvale, California, United States

Brigham and Women's Hospital

Boston, Massachusetts, United States

View Full Details on ClinicalTrials.gov

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NCT06376734


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