Endometriosis and Microvascular Dysfunction; Simvastatin and Duavee
Mechanisms and Interventions Addressing Accelerated Cardiovascular Disease Risk in Women With Endometriosis
Penn State University
28 participants
Dec 1, 2023
INTERVENTIONAL
Conditions
Summary
Purpose: To determine the effects of SERM and simvastatin interventions on endothelial dysfunction in women with endometriosis. Hypothesis: Treatment with the SERM (bazedoxifene + conjugated estrogen) or with simvastatin will decrease systemic inflammation and improve specific measures of cardiovascular function including endothelium-dependent vasodilation.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Simvastation acts as a systemic LOX inhibitor.
Duavee is a selective estrogen receptor modulator.
Locations(1)
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NCT05059626