Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma

This trial is studying CAR-T cell therapy (a treatment where your own immune cells are engineered to attack cancer) for people with HIV who also have aggressive B-cell non-Hodgkin lymphoma that has returned or not responded to prior treatments. **You may be eligible if...** - You are 18 or older and HIV-positive - You have relapsed or refractory aggressive B-cell lymphoma (DLBCL, high-grade B-cell lymphoma, primary mediastinal B-cell lymphoma, or follicular lymphoma grade 3B) - You have received at least 2 prior lines of therapy including an anthracycline and rituximab - You have evaluable disease on PET scan or bone marrow biopsy - Your kidney, liver, lung, and heart function are adequate **You may NOT be eligible if...** - You have active brain involvement from lymphoma - You have uncontrolled infections or active autoimmune disease requiring treatment - You are pregnant or breastfeeding - Your general health is too poor (ECOG > 1) Talk to your doctor to see if this trial is right for you.