Melatonin for Prevention of Kidney Injury

This study tests whether melatonin — a natural sleep hormone widely available as a supplement — can prevent kidney injury in patients who are being treated with vancomycin, a powerful antibiotic that is known to sometimes damage the kidneys. Melatonin's antioxidant properties may help protect kidney cells during antibiotic treatment. You may be eligible if... - You are between 18 and 75 years old - You are currently receiving vancomycin and are expected to continue for at least 3 days You may NOT be eligible if... - Your estimated kidney function (creatinine clearance) is below 30 mL/min - You have liver impairment (liver enzymes more than 3 times the upper limit of normal) - You have any allergy or contraindication to melatonin - You are pregnant or breastfeeding - You have an autoimmune disease - You currently require vasopressors (blood pressure–supporting medications) or mechanical ventilation - You had an acute kidney injury in the past 30 days - You are unable to take oral medications Talk to your doctor to see if this trial is right for you.