RecruitingNCT05085704
Brain Metabolism Observed at 7 Tesla
Brain Metabolism Observed at 7 Tesla in Health and Metabolic Disease.
Sponsor
University of Texas Southwestern Medical Center
Enrollment
20 participants
Start Date
May 3, 2022
Study Type
OBSERVATIONAL
Conditions
Summary
The goal is to develop methodology to monitor flux in the citric acid cycle in brain via 13C nuclear magnetic resonance (NMR) spectroscopy at 7 Tesla.
Eligibility
Min Age: 16 YearsMax Age: 65 Years
Inclusion Criteria3
- Adolescents and adults with previously documented diagnosis of Glut1 Deficiency with diagnosis genetically confirmed or confirmed by PET scan of the brain.
- Ages 16 to 65
- Persons with dental fillings, dental crowns, and short (max.4 cm) dental retainer wires can be included.
Exclusion Criteria7
- People or patients with uncontrolled seizure disorder, defined as grand mal (not absence) seizure in the preceding 3 months.
- Pregnant females will be excluded. A serum or urine pregnancy test will be administered to all females of child bearing potential within 24 hours of administration of the tracer and MRI scan. The pregnancy test will be communicated in person by the study PI. Positive results in subjects 17 years old or younger will be disclosed to parent/guardian only.
- Subjects with typical implanted orthopedic metal in bone may be considered for inclusion in a 7T scan providing the implant is not within the volume of the radio frequency coil. The PI and the AIRC Medical Director will discuss each case and determine eligibility.
- Persons with ICD, pacemakers, neurostimulators and other such devices will be excluded.
- Persons with claustrophobia are excluded.
- Persons with questionable ferrous implants, bullets, BB's, and shrapnel will be excluded.
- Subjects who are not fluent in English will be excluded because immediate cooperation and the ability to respond to instructions from the investigators are necessary.
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Interventions
DEVICEMagnetic resonance imaging
Medical imaging technique used in radiology to form pictures of the anatomy.
Locations(1)
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NCT05085704
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