RecruitingNot ApplicableNCT06607913

Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength

BCCMA: Recovery of Aged Muscle After Disuse Atrophy (REMEDY): Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength (EMPHASIS)


Sponsor

VA Office of Research and Development

Enrollment

250 participants

Start Date

Apr 11, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The aging Veteran population has more frequent inpatient hospitalization than non-Veterans. In addition, older Veterans have an inability to fully recover muscle mass and function after hospital-acquired weakness. The problem of hospital-acquired weakness is greatly increased in at-risk Veteran populations such as those with chronic kidney disease (CKD). The purpose of this collaborative study involving Denver and Baltimore VAMC sites is to improve health through the detection and rehabilitation management of hospital-acquired weakness in those with CKD. The study goals include identifying and monitoring the optimal muscle assessment sites in clinical settings, examining how muscle health impacts length of hospital stay and physical resilience, and determining how home-based and supervised exercise comparatively addresses post-hospitalization physical resilience using performance tests and Veteran feedback.


Eligibility

Min Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether a structured exercise and monitoring program can prevent muscle loss and preserve strength and overall physical function in older adults with chronic kidney disease (CKD) after they are discharged from hospital. Hospital stays often lead to significant muscle wasting, and this program aims to help patients recover better. **You may be eligible if...** - You are over 55 years old - You have been diagnosed with stage 3–4 chronic kidney disease OR your kidney filtration rate (eGFR) is below 45 mL/min/1.73m² **You may NOT be eligible if...** - You have poorly controlled high blood pressure (above 160/100) - You had a heart attack or similar cardiac event in the past 6 months - You have severe heart failure (class III or IV) or chest pain at rest or during exercise - You lost consciousness in the past year without a known resolved cause - You require home oxygen for a lung condition - You have a bleeding history in the brain or eyes, or active diabetic eye disease - You have severe spinal problems or dementia Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERExercise

The participants will exercise 2 days a week for 16 weeks. The exercises will include 4 movements: squats, shoulder press, seated row, and bicep curl focusing on internal load and contraction velocity.


Locations(2)

Rocky Mountain Regional VA Medical Center, Aurora, CO

Aurora, Colorado, United States

Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD

Baltimore, Maryland, United States

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NCT06607913


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