RCT of At-Home tDCS for Depression in Pregnancy

This study is testing whether at-home brain stimulation (called tDCS — a mild, non-invasive electrical current applied to the scalp) can reduce depression in pregnant women who do not want to take antidepressants. Participants use the device at home under remote supervision. **You may be eligible if...** - You are an adult (18 or older) who is between 12 and 32 weeks pregnant with a single baby - You are experiencing a moderate-to-severe major depressive episode (PHQ-9 score ≥ 10) - You have been offered antidepressants by a psychiatrist but declined to take them - You have not started any new treatment for depression in the 4 weeks before the study **You may NOT be eligible if...** - You have active alcohol or substance use disorder in the past 12 months - You have active suicidal thoughts - You have bipolar disorder, schizophrenia, or another psychotic disorder - You have metal implants in your skull or any electrical implants - You have a major unstable medical illness, pre-eclampsia, or a history of seizures - You are taking certain psychiatric medications (benzodiazepines above low dose, anticonvulsants) Talk to your doctor to see if this trial is right for you.