RecruitingNCT05098340

Circulating circRNA in Acute Ischemic Stroke

Clinical Significance of Circulating circRNA in Acute Ischemic Stroke (CRAST)


Sponsor

The Affiliated Hospital of Xuzhou Medical University

Enrollment

500 participants

Start Date

Oct 1, 2020

Study Type

OBSERVATIONAL

Conditions

Summary

CRAST is to analyze the expression pattern of circular RNA (circRNA) by bioinformatics analysis in patients with acute ischemic stroke and healthy control. The candidate circRNA will be verified as biomarkers for the detection and prognosis of acute ischemic stroke.


Eligibility

Min Age: 18 Years

Inclusion Criteria5

  • Aged 18 years or older
  • Confirmed acute ischemic stroke by a diffusion-weighted imaging-position lesion on magnetic resonance imaging (MRI) and a new lesion on a brain computed tomography (CT) scan
  • Within 72 hours of symptom onset
  • Good performance status
  • Signed an approved informed consents

Exclusion Criteria1

  • a history of hemorrhagic infarction, chronic kidney/liver diseases, peripheral arterial occlusive disease, active malignant disease, and inflammatory or infectious diseases

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Interventions

GENETICQuantitative Real-time polymerase chain reaction

Quantitative Real-time polymerase chain reaction of circular RNA (circRNA).


Locations(1)

Department of Neurology

Xuzhou, Jiangsu, China

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NCT05098340


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