Hypofractionated Radiation Therapy for Merkel Cell Carcinoma

This study is testing whether a shorter, more intense course of radiation therapy (called hypofractionation) is as safe and effective as the standard radiation approach for people with Merkel cell carcinoma, a rare and aggressive type of skin cancer. **You may be eligible if...** - You have been diagnosed with Merkel cell carcinoma, confirmed by biopsy - You have no evidence of cancer spreading to distant parts of the body - You have had surgery to remove the primary tumor within the last 4 months, OR - You have had lymph node surgery within the last 4 months and have specific high-risk features - Receiving immunotherapy alongside radiation is permitted **You may NOT be eligible if...** - Your cancer has spread to distant organs - You are not a candidate for radiation therapy - You have had prior radiation to the same area Talk to your doctor to see if this trial is right for you.