Merkel Cell Carcinoma Clinical Trials

17 recruiting

Merkel Cell Carcinoma Trials at a Glance

27 actively recruiting trials for merkel cell carcinoma are listed on ClinicalTrialsFinder across 6 cities in 6 countries. The largest study group is Phase 2 with 15 trials, with the heaviest enrollment activity in Houston, New York, and Pittsburgh. Lead sponsors running merkel cell carcinoma studies include Mayo Clinic, M.D. Anderson Cancer Center, and Melanoma Institute Australia.

Browse merkel cell carcinoma trials by phase

Treatments under study

About Merkel Cell Carcinoma Clinical Trials

Looking for clinical trials for Merkel Cell Carcinoma? There are currently 17 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Merkel Cell Carcinoma trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Merkel Cell Carcinoma clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 27 trials

Recruiting
Phase 1Phase 2

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

Clinical Stage III Cutaneous Melanoma AJCC v8Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic Melanoma+10 more
National Cancer Institute (NCI)16 enrolled26 locationsNCT05896839
Recruiting
Phase 1

A Study of CRD3874-SI in People With Solid Tumors

SarcomaMerkel Cell Carcinoma
Memorial Sloan Kettering Cancer Center81 enrolled7 locationsNCT06021626
Recruiting
Phase 1Phase 2

A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

MelanomaNon-small Cell Lung CancerSquamous Cell Carcinoma (Skin)+2 more
AstraZeneca60 enrolled11 locationsNCT07115043
Recruiting
Phase 2

Phase II Study of Peptide Receptor Radionuclide Therapy in Combination With Immunotherapy for Patients With Merkel Cell Cancer

Merkel Cell Carcinoma
Weill Medical College of Cornell University18 enrolled3 locationsNCT05583708
Recruiting
Phase 2

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

Advanced Colorectal CarcinomaAdvanced Anal CarcinomaAdvanced Biliary Tract Carcinoma+41 more
Mayo Clinic220 enrolled2 locationsNCT05969860
Recruiting
Phase 2Phase 3

Placebo-Controlled Trial of IFx-Hu2.0 Followed By Pembrolizumab In Checkpoint Inhibitor Naïve Participants With Advanced Or Metastatic Merkel Cell Carcinoma

Advanced Or Metastatic Merkel Cell Carcinoma
TuHURA Biosciences, Inc.118 enrolled18 locationsNCT06947928
Recruiting
Not Applicable

Electrochemotherapy (ECT) in Patients With Primary Visceral Tumors and/or Secondary Visceral Localizations, of Any Histotype

Liver CancerMelanomaMerkel Cell Carcinoma+9 more
Istituto Oncologico Veneto IRCCS24 enrolled1 locationNCT06753136
Recruiting
Phase 1

A Study of VET3-TGI in Patients With Solid Tumors

Cervical CancerNon-small Cell Lung CancerHead and Neck Squamous Cell Carcinoma+10 more
KaliVir Immunotherapeutics60 enrolled7 locationsNCT06444815
Recruiting

Studying Off Label Insurance Coverage for Patients With Cutaneous Cancers a "Filter" Observational Study

Locally Advanced Merkel Cell CarcinomaLocally Advanced Mucosal MelanomaClinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8+5 more
Ohio State University Comprehensive Cancer Center70 enrolled1 locationNCT07215988
Recruiting
Phase 1Phase 2

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Metastatic Triple-Negative Breast Carcinoma+97 more
Mayo Clinic132 enrolled1 locationNCT05269381
Recruiting
Phase 2

EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers

Skin Squamous Cell CarcinomaMerkel Cell CarcinomaCutaneous Melanoma
Ohio State University Comprehensive Cancer Center100 enrolled1 locationNCT06223659
Recruiting
Phase 1Phase 2

Study to Investigate the Efficacy and Safety of RP1 in Adult Patients With Organ Transplants and Advanced Skin Malignancies

CancerMerkel Cell CarcinomaBasal Cell Carcinoma+1 more
Replimune, Inc.90 enrolled28 locationsNCT04349436
Recruiting
Phase 2

Neoadjuvant PD-1 Blockade in Resectable Merkel Cell Carcinoma

Merkel Cell Carcinoma
Abramson Cancer Center at Penn Medicine15 enrolled1 locationNCT05496036
Recruiting
Phase 2

Neoadjuvant Nivolumab and Relatlimab in Merkel Cell Carcinoma

Merkel Cell Carcinoma
Melanoma Institute Australia20 enrolled1 locationNCT06151236
Recruiting
Phase 2

TIL Therapy in cSCC and MCC

Merkel Cell CarcinomaCutaneous Squamous Cell CarcinomaSkin Cancer+1 more
Karam Khaddour, MD, MS14 enrolled1 locationNCT07288073
Recruiting
Phase 1

Evaluating BL-M14D1 in Subjects With Locally Advanced or Metastatic Small Cell Lung Cancer and Neuroendocrine Tumors

Small Cell Lung Cancer Metastatic or Locally AdvancedNeuroendocrine CancerMetastatic or Locally Advanced Neuroendocrine Prostate Cancer+5 more
SystImmune Inc.120 enrolled20 locationsNCT07080242
Recruiting
Phase 2

Hypofractionated Radiation Therapy for Merkel Cell Carcinoma

Merkel Cell Carcinoma
M.D. Anderson Cancer Center52 enrolled1 locationNCT05100095
Recruiting
Phase 2

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

Breast CarcinomaUrothelial CarcinomaOvarian Carcinoma+26 more
Mayo Clinic27 enrolled1 locationNCT07285044
Recruiting

Liquid Biomarker Study in Melanoma and Non-Melanoma Skin Cancers

Skin CancerMelanoma (Skin Cancer)Merkel Cell Carcinoma of Skin+3 more
University of Wisconsin, Madison20 enrolled1 locationNCT06608511
Recruiting
Phase 1

A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer

MelanomaHead and Neck Squamous Cell CarcinomaMetastatic Cancer+16 more
Memorial Sloan Kettering Cancer Center56 enrolled7 locationsNCT05859074