Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers

This trial is comparing two approaches to losing weight and reducing colon cancer risk: time-restricted eating (eating only within a set window of hours each day) versus daily calorie counting and restriction. Being overweight is a known risk factor for colorectal cancer, and this study looks at which approach better reduces both weight and cancer-related markers in the body. **You may be eligible if...** - You are 45–70 years old - You have a body mass index (BMI) between 30 and 49.99 (obese range) - You are up to date with colorectal cancer screening - You are not currently on a formal weight loss program - Your weight has been stable for the past 3 months (no more than ~4 kg gained or lost) **You may NOT be eligible if...** - You have kidney disease, autoimmune disorders, serious digestive or liver disease, eating disorder, or have had bariatric (weight loss) surgery - You drink heavily, use tobacco, or have poorly controlled diabetes (HbA1c above 9%) - You have had cancer treatment in the past year, have colorectal cancer, or have a genetic predisposition like Lynch syndrome - You work night shifts or are pregnant/trying to become pregnant - Your weight exceeds 450 lbs (DXA scan limit) Talk to your doctor to see if this trial is right for you.