Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes

This study is investigating whether genetics influences how well GLP-1 receptor agonist drugs (like semaglutide or liraglutide, which help lower blood sugar and promote weight loss) work in Mexican-American people with prediabetes. The goal is to understand if certain genetic variants predict who benefits most from these medications, with the hope of more personalized diabetes prevention. **You may be eligible if...** - You are 18 or older with a diagnosis of prediabetes (slightly elevated blood sugar that has not yet reached diabetes levels) - You are at high risk for developing type 2 diabetes, defined by obesity (BMI ≥30) and/or metabolic risk factors - You are of Mexican-American heritage - You are willing to participate in the full study period including blood tests and medication **You may NOT be eligible if...** - You already have type 2 diabetes - You have a history of pancreatitis, thyroid cancer, or kidney failure - You are on blood-thinning medication or have had a heart attack or stroke in the past 6 months - You are pregnant, breastfeeding, or planning to become pregnant during the study - Your lab values (blood counts, kidney/liver function) do not meet study requirements Talk to your doctor to see if this trial is right for you.