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RecruitingPhase 3NCT05120076

Perioperative Dexamethasone Reduces Postoperative Pain and Nausea After Periacetabular Osteotomy

Perioperative Dexamethasone Reduces Postoperative Pain and Nausea After Periacetabular Osteotomy- a Double-blinded Placebo Controlled RCT

Sponsor

Balgrist University Hospital

Enrollment

60 participants

Start Date

Jul 16, 2021

Study Type

INTERVENTIONAL

Conditions

PainPostoperative NauseaAmount of Postoperative Opioid Use in Milligrams

Summary

The purpose of this study is to assess the effect of Dexamethasone on postoperative pain and nausea after periacetabular osteotomy.

Eligibility

Min Age: 18 YearsMax Age: 99 Years

Inclusion Criteria5

  • Age ≥ 18 years
  • General anasthesia
  • Elective periacetabular osteotomy for any reason
  • Written informed consent as documented by signature (Appendix Informed Consent Form)
  • Competent German language skills

Exclusion Criteria9

  • Chronic pain patient, chronic lower back pain
  • Steroid or immunosuppressive drugs used within 6 months of surgery
  • Renal failure, hepatic failure
  • Relevant allergies
  • Pregnancy/ Breast feeding
  • Contraindications for Fortecortin treatment according to Swissmedic
  • Previous enrollment into the current study
  • Participation in another study with investigational drug within the 30 days preceding and during the present study
  • Known or suspected non-compliance, drug or alcohol abuse Illness according to "Warnings and Precautions of Dexamethasone and NaCl"

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Interventions

DRUGDexamethasone 4 Mg/mL Injectable Solution

s. arm/group description

DRUGNaCl 0.9%

s. arm/group description

Locations(1)

Uniklinik Balgrist

Zurich, Switzerland

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NCT05120076

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