RecruitingNCT05138263

Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's disease2 (KBASE2)

Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's disease2

Sponsor

Seoul National University Hospital

Enrollment

640 participants

Start Date

Jan 1, 2022

Study Type

OBSERVATIONAL

Conditions

Alzheimer Disease Mild Cognitive Impairment

Summary

The KBASE2 is the second phase of the KBASE project, which consists of roll-over participants from the first phase of the KBASE as well as newly enrolled participants with varying degrees of cognitive functions (e.g. individuals with normal cognition, mild cognitive impairment, or AD dementia). In addition to the aims of the first phase of the KBASE, the KBASE2 will focus on new data collection and integrative analysis of the rich structural, functional, and molecular neuroimaging data in relation to whole genome sequencing and other -omics. Network analysis of disruption in brain connectivity in relation to clinical status and AD biomarker profiles also will be conducted.

Eligibility

Min Age: 20 YearsMax Age: 90 Years

Inclusion Criteria20

Age : 55 - 90
Clinical Dementia Rating (CDR)=0.5 or 1
Diagnostic and Statistical Manual-IV(DSM-IV) criteria for dementia
National Institute of Aging and the Alzheimer's Association (NIA-AA) Probable AD dementia
Study partner or caregiver to accompany patient to all scheduled visits
Written informed consent
Age : 55 - 90
Clinical Dementia Rating (CDR)=0.5
Concern regarding a change in cognition (obtained from the subject, from an informant who knows the subject, or from a skilled clinician observing the subject)
Lower performance in any cognitive domain that is greater than would be expected for the subject's age and educational background
Preservation of independence in functional abilities
Study partner or caregiver to accompany subject to all scheduled visits
Written informed consent
Age : 55 - 90
Clinical Dementia Rating (CDR)=0
Those with contactable Informant
Written informed consent
Age : 20 - 54
Clinical Dementia Rating (CDR)=0
Written informed consent

Exclusion Criteria7

Past history or presence of major psychiatric illness (e.g. schizophrenia, bipolar disorder, alcohol/substance abuse or dependence, delirium)
Significant neurologic or medical condition that can influence the mental state
Contraindications for MRI scan (e.g. pacemaker, claustrophobia)
Illiteracy
Significant visual or hearing difficulty
Taking investigational drug
In pregnancy or breast-feeding