RecruitingNCT05171725

Multidisciplinary Expert System for the Assessment & Management of Complex Brain Disorders


Sponsor

Neurological Institute of Athens

Enrollment

350 participants

Start Date

Apr 1, 2021

Study Type

OBSERVATIONAL

Conditions

Summary

The Multidisciplinary Expert System for the Assessment \& Management of Complex Brain Disorders (MES-CoBraD) is an interdisciplinary project combining Real-World Data (RWD) from multiple clinical and consumer sources through comprehensive, cost-efficient, and fast protocols towards improving diagnostic accuracy and therapeutic outcomes in people with Complex Brain Disorders (CoBraD), as reflected in Neurocognitive (Dementia), Sleep, and Seizure (Epilepsy) disorders and their interdependence. It brings together internationally recognized experts in medicine, engineering, computer science, social health science, law, and marketing and communication from across Europe, and combines clinical information and scientific research in CoBraD with technical innovation in secure data-sharing platforms, artificial intelligence algorithms, and expert systems of precision and personalized care, with a primary focus on improving the quality of life of patients, their caregivers, and the society at large. It leverages RWD from diverse CoBraD populations across cultural, socioeconomic, educational, and health system backgrounds, with special attention on including vulnerable populations and minorities in an equitable manner and engaging key stakeholders to maximize project impact.


Eligibility

Plain Language Summary

Simplified for easier understanding

This study is developing a multidisciplinary expert system to improve how doctors assess and manage complex brain disorders, including epilepsy, memory and thinking problems (neurocognitive disorders), and sleep disorders. Both patients attending the clinics and healthy volunteers are being enrolled. **You may be eligible if...** - You are willing to undergo a comprehensive assessment - You are attending one of three specialty clinics (epilepsy, neurocognitive disorders, or sleep disorders) at the participating center - OR you are a healthy volunteer **You may NOT be eligible if...** - You are not interested in participating Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTEEG,PSG

concurrent overnight sleep study with full electroencephalography (in-lab or at home)

DIAGNOSTIC_TESTbiosample collection (blood and CSF)

blood or CSF collection for analyses of neurodegenerative, inflammatory, and, per condition, genetic information

DIAGNOSTIC_TESTneuropsychological testing

paper and pencil, as well as tablet based cognitive testing

DIAGNOSTIC_TESTactigraphy

week long actigraphy assessment with concurrent sleep diary acquisition

DIAGNOSTIC_TESTclinician assessment

standard clinical assessment by an expert clinician in the respective field of brain disorders


Locations(4)

Neurological Institute of Athens

Athens, Greece

Rabin Medical Center

Petah Tikva, Israel

Sant Pau Memory Clinic

Barcelona, Spain

King's College London

London, United Kingdom

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT05171725


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