RecruitingNCT05171725

Multidisciplinary Expert System for the Assessment & Management of Complex Brain Disorders


Sponsor

Neurological Institute of Athens

Enrollment

350 participants

Start Date

Apr 1, 2021

Study Type

OBSERVATIONAL

Conditions

Summary

The Multidisciplinary Expert System for the Assessment \& Management of Complex Brain Disorders (MES-CoBraD) is an interdisciplinary project combining Real-World Data (RWD) from multiple clinical and consumer sources through comprehensive, cost-efficient, and fast protocols towards improving diagnostic accuracy and therapeutic outcomes in people with Complex Brain Disorders (CoBraD), as reflected in Neurocognitive (Dementia), Sleep, and Seizure (Epilepsy) disorders and their interdependence. It brings together internationally recognized experts in medicine, engineering, computer science, social health science, law, and marketing and communication from across Europe, and combines clinical information and scientific research in CoBraD with technical innovation in secure data-sharing platforms, artificial intelligence algorithms, and expert systems of precision and personalized care, with a primary focus on improving the quality of life of patients, their caregivers, and the society at large. It leverages RWD from diverse CoBraD populations across cultural, socioeconomic, educational, and health system backgrounds, with special attention on including vulnerable populations and minorities in an equitable manner and engaging key stakeholders to maximize project impact.


Eligibility

Inclusion Criteria1

  • All participants willing to undergo comprehensive assessment who visit one of three clinics (Epilepsy, Neurocognitive disorders, and Sleep Disorders), and healthy volunteers

Exclusion Criteria1

  • participant disinterest

Interventions

DIAGNOSTIC_TESTEEG,PSG

concurrent overnight sleep study with full electroencephalography (in-lab or at home)

DIAGNOSTIC_TESTbiosample collection (blood and CSF)

blood or CSF collection for analyses of neurodegenerative, inflammatory, and, per condition, genetic information

DIAGNOSTIC_TESTneuropsychological testing

paper and pencil, as well as tablet based cognitive testing

DIAGNOSTIC_TESTactigraphy

week long actigraphy assessment with concurrent sleep diary acquisition

DIAGNOSTIC_TESTclinician assessment

standard clinical assessment by an expert clinician in the respective field of brain disorders


Locations(4)

Neurological Institute of Athens

Athens, Greece

Rabin Medical Center

Petah Tikva, Israel

Sant Pau Memory Clinic

Barcelona, Spain

King's College London

London, United Kingdom

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NCT05171725


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