Cardiopulmonary Bypass Induced Red Blood Cell Lysis
Extra-Cellular Hemoglobin, Organ Injury in Extended Cardiopulmonary Bypass
University of Maryland, Baltimore
150 participants
Mar 22, 2022
OBSERVATIONAL
Conditions
Summary
Studying the dynamics of red blood cell lysis, pfH, protective proteins and organ injury, limits will be set for safe levels of pfH following the use of CPB. These results will be compared to existing laboratory-based methods for determining red blood cell damage to predict CPB assist device safety. Further, results from the studies described in this proposal will help develop therapeutic strategies to benefit patients by early detection of pfH and clearance protein levels that occur during CPB.
Eligibility
Inclusion Criteria3
- Admitted to UMMC for cardiac procedure
- Age: \>/=18 y.o TO 88 y.o.
- Undergoing CPB \>1hr for the following surgeries (a) complex cardiac surgery (b) heart valve replacement surgery OR (c) CABG surgery.
Exclusion Criteria3
- Pregnant
- Non English speaking
- Unable to consent or have Legally Authorized Representative (LAR) assent to study
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
No intervention - Biological specimen collection
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05189262