RecruitingNot ApplicableNCT05189496

Hyperbaric Oxygen in the Prevention of Radiation Pneumonitis

Study on the Effectiveness and Safety of Hyperbaric Oxygen Therapy for Preventing Radiation Pneumonitis Caused by Radiotherapy and Chemotherapy of Breast Cancer

Sponsor

Guangdong Provincial People's Hospital

Enrollment

380 participants

Start Date

Mar 1, 2022

Study Type

INTERVENTIONAL

Conditions

Radiation Pneumonitis

Summary

Radiotherapy is one of the important treatments to improve the survival rate of breast cancer patients, but also has the risk of radiation lung injury, which can develop into pulmonary fibrosis. Hyperbaric oxygen can improve the tissue after radiation by promoting the function of vascular endothelial cells and fibroblasts, and reducing the secretion of inflammatory factors, thereby inhibiting the process of fibrosis and fiber atrophy after radiotherapy, and promoting tissue repair. Therefore, it has the potential value of treating chronic radiation injury. We aim to investigate whether hyperbaric oxygen treatment can reduce the incidence of radiation pneumonia and improve patients' quality of life, and to evaluate its safety and the impact on the patients' long-term survival outcomes.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can help prevent radiation-induced lung inflammation (radiation pneumonitis) in breast cancer patients who have completed radiation therapy. **You may be eligible if...** - You have been previously diagnosed with breast cancer and completed radical surgery, chemotherapy, and radiation - You are between 18 and 70 years old - Your cancer has not spread to distant organs or recurred only as neck lymph nodes - Your expected survival is at least 2 years - You have no signs of radiation-related lung injury before starting hyperbaric treatment **You may NOT be eligible if...** - You have lung conditions that make hyperbaric oxygen unsafe (severe COPD, lung bullae, uncontrolled asthma, pneumothorax) - You have had ear surgery or significant ear/eye problems - You have already received hyperbaric oxygen therapy - You already have radiation pneumonia - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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