RecruitingNCT06557343

Single-Cell Sequencing Analysis of Radiation Pneumonitis Signals In Patients Treated For Cancer With Radiotherapy

Sponsor

NHS Lothian

Enrollment

5 participants

Start Date

Oct 25, 2024

Study Type

OBSERVATIONAL

Conditions

Radiation Pneumonitis

Summary

Patients with signs of radiation induced lung inflammation, who are referred for a clinical bronchoscopy for investigation, will have a sample sent for single cell sequencing. This is a novel technique which allows for identification of which cells are present and what they are doing. This hopes to better understand radiation pneumonitis, a dose-limiting toxicity in cancer treatment which can be highly morbid and even fatal.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating what happens in the lungs at a cellular level during radiation pneumonitis — an inflammation of the lungs that can occur after chest radiation therapy for cancer. Researchers will use a procedure called bronchoscopy (a thin tube into the airways) to collect samples and analyze them with advanced genetic sequencing. **You may be eligible if...** - You are 18 or older and have received radiation therapy to the chest - You are showing signs of radiation pneumonitis (breathlessness, cough, chest discomfort that started 1–4 months after treatment) - You are well enough to safely undergo a bronchoscopy (you can lie flat, breathe without oxygen, and are medically stable) **You may NOT be eligible if...** - You cannot safely undergo bronchoscopy (e.g., cannot lie flat, oxygen saturation below 92%, previously didn't tolerate the procedure) - You need to be hospitalized or are dependent on supplemental oxygen - You tested positive for COVID-19 within the last 6 weeks Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTSingle Cell Sequencing

Sequencing of all viable single cells present in deep bronchial brushings using transcriptomics to identify what cells are present and what they are doing.