RecruitingNCT05204459

MS-ResearchBiomarkerS

Investigating the Longitudinal Relationships Between Visual Pathway Injury, Radiological and Blood Biomarkers in Multiple Sclerosis and Related Disorders

Sponsor

Cedars-Sinai Medical Center

Enrollment

1,000 participants

Start Date

Nov 11, 2021

Study Type

OBSERVATIONAL

Conditions

Neurologic Disorder Multiple Sclerosis Clinically Isolated Syndrome Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease Healthy Aging Neuromyelitis Optica Spectrum Disorders Multiple Sclerosis, Relapsing-Remitting Radiologically Isolated Syndrome Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Primary Progressive Neurologic Autoimmune Disease

Summary

This study is being conducted to investigate risk factors for disability progression in Multiple Sclerosis and related disorders (MSRD). The primary goal is to assess whether combining information from visual assessment, blood markers, as well as historical and ongoing longitudinal MRIs of the brain, orbit (the part of the skull where eyes are located), and/or spinal cord can predict changes in quantitative disability measures related to MSRD and neurological disease.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting blood, spinal fluid, and other samples from people with multiple sclerosis and related conditions to search for new biological markers (biomarkers) that can help diagnose, monitor, and better understand these diseases. **You may be eligible if...** - You are 18 or older - You have been diagnosed with multiple sclerosis (MS), a clinically isolated syndrome (CIS), radiologically isolated syndrome (RIS), neuromyelitis optica (NMOSD), MOG-related disease, or another neurological condition - You are a healthy volunteer (also eligible) **You may NOT be eligible if...** - You have a metal implant or other condition preventing an MRI (for the MRI parts of the study) - You are pregnant (for some portions of the study) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Cedars-Sinai Medical Center

Los Angeles, California, United States

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NCT05204459

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