RecruitingNot ApplicableNCT05205954

HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease

Sponsor

Massachusetts General Hospital

Enrollment

30 participants

Start Date

Jul 21, 2025

Study Type

INTERVENTIONAL

Conditions

Cirrhosis

Summary

This research study is evaluating a program that entails a healthcare at home intervention for people with advanced liver disease.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Adult patients ≥ 18 years old with diagnosis of cirrhosis based on histology, radiology, and/or elastography presenting to the emergency department or inpatient general medicine service
Patients must have one of the following:
Ascites (requiring diuretics or serial large volume paracenteses)
Hepatic hydrothorax (requiring diuretics)
Hepatic encephalopathy (requiring medications)

Exclusion Criteria7

History of solid organ transplantation
On hemodialysis
MELD score > 20
Score <10 on Simplified Animal Naming Test (S-ANT1)
Current admission for hemodynamically significant GI bleeding or alcohol withdrawal
Require routine administration of controlled substances
Those deemed ineligible based on the MGH Home Hospital, inpatient medicine or hepatology clinician evaluation

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Interventions

BEHAVIORALHepatology Home Hospital

The Hepatology Home Hospital intervention entails the following: patient-reported symptoms and vital signs with appropriate triggers for phone calls and home visits, and regular communication with hepatology clinicians regarding care delivered at home to ensure continuity of care.