Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial

This study is testing whether clozapine, an antipsychotic medication, is more effective than other standard psychiatric medications at reducing violent behavior in people with schizophrenia or schizoaffective disorder. Clozapine has been used for decades but this trial specifically examines its potential to prevent violence. **You may be eligible if...** - You have a diagnosis of schizophrenia or schizoaffective disorder - You have committed a minor or serious act of violence in the last 6 months - You are medically stable - You are willing and able to provide informed consent - Both clozapine and standard treatment are considered medically appropriate options for you **You may NOT be eligible if...** - You have an unstable or serious medical condition affecting the bone marrow - You have a history of serious reactions to clozapine (such as dangerous low white blood cell counts, bowel obstruction, or heart inflammation) - You have an intellectual disability - You are pregnant, breastfeeding, or unwilling to use birth control - You have a high and immediate risk of suicide Talk to your doctor to see if this trial is right for you.