Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

This study investigates how sex differences (male vs. female) affect how blood vessels respond to low oxygen levels (hypoxic vasodilation) and how obesity changes this response. Understanding these differences could lead to better treatments for conditions like high altitude illness and heart disease. You may be eligible if: - You are between 18 and 45 years old - Your BMI is above 18 kg/m² You may NOT be eligible if: - You are pregnant or breastfeeding - You have diagnosed sleep apnea or more than 10 breathing pauses per hour during sleep - You currently smoke or use nicotine products - You have a bleeding disorder or are on anticoagulation therapy - You have any nerve or neurological disease - You have cardiovascular, liver, kidney, or respiratory disease - Your blood pressure is 140/90 mmHg or higher - You have diabetes or polycystic ovarian syndrome - You are taking prescription medications - You are sensitive or allergic to lidocaine Talk to your doctor to see if this trial is right for you.