RecruitingNot ApplicableNCT05226247
Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study)
Evaluation of the Role of Systolic Dysfunction in Weaning Failure Related to Weaning-induced Pulmonary Edema: the SystoWean Study
Sponsor
Centre Hospitalier Universitaire de Nice
Enrollment
250 participants
Start Date
Aug 8, 2022
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to determine if the left and right ventricular systolic function is involved in the development of weaning failure related to weaning-induced pulmonary edema.
Eligibility
Min Age: 18 Years
Inclusion Criteria9
- Invasive mechanical ventilation for more than 48 hours
- Patients indicated, according to intensivists, for carrying out a spontaneous breathing trial weaning test, based on the presence of all of the following criteria:
- SpO2> 90% with FiO2 ≤40% and PEEP ≤5 cmH2O
- Cough effectiveness on tracheal aspirations
- Lack of hemodynamic instability and of disorders of consciousness
- Patients at high risk of weaning-induced pulmonary edema (WIPO), defined by one or more of the following criteria:
- Obesity, defined by a body mass index> 30 kg/m²
- Chronic obstructive pulmonary disease
- Chronic heart disease
Exclusion Criteria7
- Age <18 years and pregnant women
- Patients with a decision of not to resuscitate
- Poor echogenicity
- Severe mitral valve disease (leakage and/or stenosis, bioprosthesis)
- Patients with pacemaker
- Tracheostomy
- Chronic neuromuscular or neurodegenerative diseases
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Interventions
PROCEDURESpontaneous breathing trial
To perform cardiac and lung echography before and during a spontaneous breathing trial
Locations(3)
View Full Details on ClinicalTrials.gov
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NCT05226247
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