RecruitingPhase 1NCT05226494

Safety and Tolerability of Fb-PMT in Recurrent Glioblastoma

A Phase 1 Trial to Evaluate the Safety and Tolerability of Fb-PMT in Patients With Recurrent Glioblastoma


Sponsor

NanoPharmaceuticals LLC

Enrollment

34 participants

Start Date

Jun 23, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Glioblastoma is a highly aggressive and fatal form of primary malignant brain tumor with limited treatment options. fb-PMT affects a large group of cancer cell signaling pathways and thus may be effective in heterogeneous, treatment-resistant tumors such as Glioblastoma. fb-PMT also is actively transported across the blood-brain barrier into the brain. This study is being conducted to determine the dose level for further clinical development of fb-PMT to treat recurrent Glioblastoma.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is evaluating a new treatment called Fb-PMT (a photodynamic therapy agent) for patients with glioblastoma — a severe brain tumor — whose cancer has come back after initial treatment. The study focuses on safety and tolerability of this approach. **You may be eligible if...** - You have been diagnosed with glioblastoma confirmed by biopsy - Your tumor has come back for the first or second time (first or second recurrence) - You have completed and recovered from standard prior treatment - You are on a stable or decreasing dose of steroids - You have had a recent MRI scan **You may NOT be eligible if...** - You are on increasing doses of steroids indicating rapid disease worsening - You have uncontrolled seizures - You have serious organ dysfunction (kidney, liver) - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGfb-PMT

Daily dosing based on patient weight


Locations(1)

Smilow Cancer Hospital

New Haven, Connecticut, United States

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NCT05226494


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