Childhood Traumas in Obese Women: Association With Deregulation of the Glucocorticoid Axis and Inflammatory State.

Exclusion Criteria16

• History of bariatric surgery
• Any condition or pathology that may influence the corticotropic axis or that may modify the excretion or dosage of cortisol:
• pregnancy, breastfeeding
• hepatocellular insufficiency,
• severe heart failure,
• mild/moderate acute heart failure,
• any psychological disorder not stabilised for at least one year
• alcohol or drug dependence, not weaned for at least one year
• neoplasm under treatment
• Current infectious disease or a history of autoimmune disease (except autoimmune hypothyroidism), inflammatory disease and/or neurodegenerative disease
• Presence of an adrenal adenoma or any known or suspected clinical adrenal or corticotropic disorder
• Subjects with a positive diagnosis of hypercorticism or suspected hypercorticism will also be excluded: 8-hour plasma cortisol after Dexamethasone suppression test (DST) (1 mg dexamethasone taken orally at midnight the previous day) greater than 1.8 microg/100 ml (50 nmol/l)
• antidepressant and neuroleptic treatment, benzodiazepine treatment
• treatment(s) likely to modify the exploration of the corticotropic axis: systemic or local corticosteroid therapy or glucocorticoid infiltration for less than 6 months
• current use of anti-inflammatory drugs or antibiotics
• Shift worker