Prehabilitation for Patients Awaiting Liver Transplantation
Does a Multimodal Prehabilitation Program Improve Markers of Frailty in Patients With Cirrhosis Undergoing Liver Transplantation? A Feasibility Trial
McGill University Health Centre/Research Institute of the McGill University Health Centre
25 participants
Feb 23, 2022
INTERVENTIONAL
Conditions
Summary
This study will assess the feasibility, safety and effectiveness of a structured prehabilitation program combining exercise training, nutritional optimization and psychological support for patients with cirrhosis awaiting liver transplantation.
Eligibility
Inclusion Criteria3
- Age above 18 years
- Diagnosis of cirrhosis, based on a combination of clinical, laboratory, imaging, or histology
- Active on the liver transplant waiting list of the MUHC
Exclusion Criteria11
- Biological Model for End Stage Liver Disease >20
- Hepatic decompensation within the last month
- High risk varices not on primary or secondary prevention
- Recurrent large volume paracentesis
- Persistent hepatic encephalopathy
- Platelets <20,000/µL, or hemoglobin <80g/L
- Altered hemodynamics
- Significant heart disease
- Awaiting combined organ transplantation
- Awaiting repeat liver transplantation
- Condition limiting mobilization and/or exercise, or recurrent falls
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Interventions
All participants will be offered a multimodal prehabilitation program. This program will include an individualized and supervised aerobic and resistance exercise training program, nutritional optimization, and psychological support. The program will last 6 months or until liver transplantation, whichever comes first.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05237583