Using ctDNA to Detect Minimal Residual Disease After Lung Cancer Resection

This study is examining whether a blood test that detects fragments of cancer DNA circulating in the bloodstream (called ctDNA) can identify remaining cancer cells after lung cancer surgery. If ctDNA is detected after surgery, it may mean the cancer is likely to return, allowing doctors to intervene earlier. **You may be eligible if...** - You are 18 or older - You have non-small cell lung cancer (NSCLC) that has not spread to lymph nodes or other organs (T1-T4 N0M0) - You are scheduled for a complete surgical removal of your lung cancer - Your tumor is at least 1 cm and has some solid component on imaging - A tissue sample from your tumor will be available for the study **You may NOT be eligible if...** - You have had prior radiation, surgery, or chemotherapy for this lung cancer - Your surgery cannot completely remove the tumor - You are enrolled in another study using drugs or radiation - You have another active cancer diagnosed within the last 2 years - You are pregnant Talk to your doctor to see if this trial is right for you.