RecruitingNot ApplicableNCT05266976

Mode of Exercise and Bone Biomarkers in Older Veterans

Anabolic Versus Catabolic Skeletal Effects of Endurance or Resistance Exercise in Older Veterans


Sponsor

VA Office of Research and Development

Enrollment

120 participants

Start Date

Jul 6, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain why bone does not always favorably adapt to exercise, but it is unclear if this also happens with resistance exercise. Further, it is not known how exercise training influences blood markers of bone resorption for either endurance or resistance exercise. The purpose of this study is to determine 1) if resistance exercise causes a similar increase in bone resorption as endurance exercise; and 2) if exercise training influences the increase in bone resorption following exercise for both endurance and resistance exercise.


Eligibility

Min Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a behavioral approach called 10 Weeks of Supervised Endurance Exercise Training and a behavioral approach called 10 Weeks of Supervised Resistance Exercise Training for people with aging, musculoskeletal diseases, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 60 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORAL10 Weeks of Supervised Resistance Exercise Training

Participants will be randomized to complete 10 weeks of either resistance (weight lifting, hopping) supervised exercise. Exercise will be 3x per week for 1 hour each session. There are a total of 30 exercise sessions.

BEHAVIORAL10 Weeks of Supervised Endurance Exercise Training

Participants will be randomized to complete 10 weeks of endurance (stationary cycling) supervised exercise. Exercise will be 3x per week for 1 hour each session. There are a total of 30 exercise sessions.


Locations(1)

Rocky Mountain Regional VA Medical Center, Aurora, CO

Aurora, Colorado, United States

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NCT05266976


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