RecruitingNCT05267158

The Cohort for Patient-reported Outcomes, Imaging and Trial Inclusion in Metastatic BRAin Disease (COIMBRA)

Sponsor

UMC Utrecht

Enrollment

1,000 participants

Start Date

Apr 26, 2019

Study Type

OBSERVATIONAL

Conditions

Brain Metastases, Adult Brain Neoplasms, Adult, Malignant

Summary

The incidence of brain metastases is expected to increase because of better treatments of primary tumours. Novel diagnostic and therapeutic techniques are continuously being developed, all of which need thorough evaluation before they can be implemented in clinical routine. Randomized Controlled Trials are the gold standard to do so, but they have shown many challenges, especially when applied in a cancer setting. .The 'cohort multiple Randomized Controlled Trial (cmRCT)' design is a promising design for multiple (simultaneous) randomized evaluations of experimental interventions, with potential for increased recruitment, comparability and long-term outcomes as a standard. This design will speed up the process of translating treatment innovations to the daily clinic.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting patient-reported outcomes, brain imaging data, and treatment information from people with cancer that has spread to the brain (brain metastases) who are being referred for brain radiation therapy. The goal is to better understand quality of life and treatment outcomes in this group, and to help identify patients suitable for future clinical trials. **You may be eligible if...** - You are 18 years or older - You have been confirmed to have brain metastases by imaging or biopsy, or you are being considered for preventive brain irradiation - You have been referred to the radiotherapy department for brain radiation treatment **You may NOT be eligible if...** - You have a mental disorder or cognitive difficulties that prevent you from understanding the study details or giving consent - You have severe psychiatric illness - You do not understand Dutch Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

University Medical Center Utrecht

Utrecht, Netherlands

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NCT05267158

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