Preoperative vs Postoperative Hypofractionated Radiosurgery for Patients With Large Brain Metastases

This trial is comparing two approaches to using a focused form of radiation (radiosurgery) for people with large brain metastases who need surgery — giving radiation before the operation versus after. Researchers want to find out which approach is safer and more effective. **You may be eligible if...** - You are over 18 years old - You have a confirmed solid tumor cancer that has spread to the brain - You have 1 to 4 brain metastases, with at least one that is 2.1 cm or larger and requires surgery - You are in good physical condition (Karnofsky score of 70 or higher) - Your cancer outside the brain is controlled or responding to treatment **You may NOT be eligible if...** - You have more than 4 brain metastases - You have had whole-brain radiation before - Your cancer is small cell lung cancer, lymphoma, or a germ cell tumor - You are pregnant - You have had previous brain surgery for cancer Talk to your doctor to see if this trial is right for you.