Adjuvant Chemoradiation and Biomarkers of Response in High-risk Breast Cancer

This study examines biological markers in people with high-risk breast cancer who received chemotherapy before surgery (neoadjuvant chemotherapy) but still had cancer remaining after surgery. These patients then receive additional radiation and/or chemotherapy, and the study tracks how well they respond. **You may be eligible if...** - You are 18 or older (male or female) - You have been diagnosed with stage I–IIIB breast cancer - You received at least 3 cycles of chemotherapy before surgery - Cancer was still found in your breast or lymph nodes after surgery - You are scheduled to receive additional radiation as part of your standard care - Your radiation is planned to start within 12 weeks of your last surgery - Your heart function (ejection fraction) is at least 45% if you will receive a drug called TDM-1 **You may NOT be eligible if...** - Your breast cancer was fully eliminated by pre-surgery chemotherapy - You have significant heart problems or other serious organ issues - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.