RecruitingNot ApplicableNCT05299749

Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations

Real-time fMRI Neurofeedback as a Tool to Mitigate Auditory Hallucinations in Patients With Schizophrenia - R33 Phase


Sponsor

Boston VA Research Institute, Inc.

Enrollment

104 participants

Start Date

Mar 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Neurofeedback intervention aimed to regulate the superior temporal gyrus (STG) activation and default mode network (DMN) connectivity as well as to reduce the auditory hallucinations (AH) schizophrenia patients with medication resistant AH.


Eligibility

Min Age: 18 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study uses real-time brain scanning (fMRI neurofeedback) to help people with schizophrenia control the brain activity linked to hearing voices (auditory hallucinations). Participants learn to regulate their own brain activity while watching live feedback on a screen. **You may be eligible if...** - You have been diagnosed with schizophrenia or schizoaffective disorder - You experience auditory hallucinations (hearing voices) that have not fully responded to medication **You may NOT be eligible if...** - You have a neurological illness or significant head trauma - You have had electroconvulsive therapy (ECT) - You have current or recent alcohol or drug dependence - Your verbal IQ is below 70 Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERstg-rt-fMRI-Neurofeeback

the patients will receive real-time feedback from the brain activity of the superior temporal gyrus

OTHERsham-rt-fMRI-Neurofeedback

the patients will receive real-time feedback from the brain activity of the somato-motor cortex


Locations(1)

Boston VA Healthcare System, Brockton

Brockton, Massachusetts, United States

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NCT05299749


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