Quantifying Hepatic Mitochondrial Fluxes in Humans

This study measures how the liver processes energy in people with type 2 diabetes and fatty liver disease (a condition where fat builds up in the liver). Using special metabolic tests, it aims to understand how the liver's energy system (mitochondria) works and how it might be improved. **You may be eligible if...** - You have type 2 diabetes, confirmed by a glucose tolerance test - You are 18–80 years old with a BMI between 25–40 kg/m² - Your HbA1c (blood sugar measure) is between 7–10% and your weight has been stable recently - You have moderate-to-severe fatty liver confirmed by imaging - You are managed with diet, metformin, or sulfonylurea only **You may NOT be eligible if...** - You drink more than 14 units of alcohol per week - You take medications that significantly affect blood sugar beyond the allowed types - You have significant liver scarring (fibrosis) beyond early stages Talk to your doctor to see if this trial is right for you.