RecruitingNot ApplicableNCT05307809

Cytokine Expression in Psoriasis Patients with and Without Joint Involvement

Cytokine Expression in Sera, Ex Vivo Stimulated Peripheral Blood Mononuclear Cells Culture, and Skin in Psoriasis - Comparison of Patients with and Without Joint Involvement

Sponsor

Poitiers University Hospital

Enrollment

40 participants

Start Date

Aug 17, 2022

Study Type

INTERVENTIONAL

Conditions

Psoriasis Psoriatic Arthritis

Summary

The objective of the resarch is to study the cytokine profile of patients with psoriatic arthritis and psoriasis in order to better understand the pathophysiology of the disease and the contribution of cytokines to the presence or absence of joint involvement. This research will compare cytokines levels in sera, in PBMC culture after LPS or CD3/CD28 agonist antibodies, and in skin biopsy.

Eligibility

Min Age: 18 YearsMax Age: 100 Years

Inclusion Criteria19

For psoriasis patients :
Age over 18 years old
Signed informed consent
year old psoriasis at least
At least one skin lesion over 2 cm
Without any articular symptoms
Without any DMARDs
Without anticoagulant treatments or coagulation disease
With normal articular and enthesis sonography
For psoriatic arthritis patients :
Age over 18 years old
Signed informed consent
Psoriatic arthritis according to CASPAR criteria
Without any DMARDs
Without anticoagulant treatments or coagulation disease
With at least one synovitis at inclusion
For controls
Age and sex matched with a patient without any rheumatic or dermatologic medical conditions
No treatment with corticosteroïds or non-steroïdial anti-inflammatory drugsAge over 18 years old

Exclusion Criteria6

▪ For psoriasis patients :
Joint damage according to CASPAR criteria
Echography activity in favor of chronic inflammatory rheumatism
For patients and controls:
Without social protection rights
People under judiciary protection, of less than 18 years old, pregnant woman, breast feeding women, jailed patients.