RecruitingNCT05309746

Ovarian Tissue Cryopreservation in Post Pubertal (OTC-Post Pubertal)

Ovarian Tissue Cryopreservation for Fertility Preservation in Post-Pubertal Children Facing a Fertility Threatening Diagnosis or Treatment Regimen

Sponsor

Erin Rowell

Enrollment

250 participants

Start Date

Nov 1, 2017

Study Type

OBSERVATIONAL

Conditions

Pediatric Cancer

Summary

The purpose of this study is to safely remove ovarian tissue in pediatric patients, who are at risk for infertility from their medical treatment, for freezing for future restoration of fertility and hormone function.

Eligibility

Sex: FEMALEMax Age: 30 Years

Plain Language Summary

Simplified for easier understanding

This study collects and freezes ovarian tissue from young people (after puberty, under 30) before they undergo cancer treatments or surgeries that could damage their fertility. The frozen tissue may later be transplanted back to restore hormone function or potentially allow pregnancy. **You may be eligible if...** - You are post-pubertal and under 30 years old - You are about to have surgery, chemotherapy, or radiation that puts your fertility or ovarian function at risk (such as total body irradiation, high-dose alkylating chemotherapy, or pelvic radiation of 10 Gy or more) - You are facing a health condition or cancer requiring removal of one or both ovaries **You may NOT be eligible if...** - You already have signs of ovarian failure or insufficient ovarian reserve - Your cancer has likely spread to the ovaries (which would make reimplantation unsafe) - You do not meet the medical eligibility criteria for surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURELaparoscopic surgery

Surgery used to remove the child's ovary tissue is called laparoscopic surgery. Laparoscopic surgery employs a telescope-like instrument called laparoscope. The laparoscope will be put into the child's belly through a small (about half an inch) cut just below the belly button. Two or three other cuts may be made to allow for other instruments to help remove one of the ovaries. The surgeon will then look at both ovaries before the removal of one. Both of the child's ovaries must appear normal and be free of any masses in order to complete the surgery. The surgeon will choose which ovary will be removed at the time of surgery. This type of surgery is likely to last for 30 to 65 minutes.