Weight Management Plus Megestrol Acetate in Early-stage Endometrioid Carcinoma

This study tests whether adding a weight management program to megestrol acetate (a hormone treatment) improves outcomes for younger women with early-stage, low-grade uterine cancer (endometrioid carcinoma G1) who want to preserve their fertility. Standard treatment is hysterectomy, but some women wish to avoid this. **You may be eligible if...** - You are between 18 and 45 years old - Your BMI is 24 or higher (overweight or obese) - You have a confirmed diagnosis of grade 1 endometrioid endometrial carcinoma based on hysteroscopy or biopsy - Imaging shows no signs of cancer spreading beyond the uterus - You have already tried and failed progestin (progesterone-based) treatment as your first-line therapy **You may NOT be eligible if...** - Your cancer has spread to the muscle of the uterine wall or beyond - You have serious health conditions that prevent participation in weight management - You are pregnant or planning an immediate pregnancy Talk to your doctor to see if this trial is right for you.