Overweight Clinical Trials

485 recruitingLast updated: June 17, 2026

There are 485 actively recruiting overweight clinical trials across 58 countries. Studies span Not Applicable, Phase 1, Phase 3, Phase 2, Phase 4, Early Phase 1. Top locations include Houston, Texas, United States, Dallas, Texas, United States, San Antonio, Texas, United States. Updated daily from ClinicalTrials.gov.


Overweight Trials at a Glance

485 actively recruiting trials for overweight are listed on ClinicalTrialsFinder across 6 cities in 58 countries. The largest study group is Not Applicable with 252 trials, with the heaviest enrollment activity in Houston, Dallas, and San Antonio. Lead sponsors running overweight studies include Eli Lilly and Company, Novo Nordisk A/S, and Johns Hopkins University.

Browse overweight trials by phase

Treatments under study

About Overweight Clinical Trials

Looking for clinical trials for Overweight? There are currently 188 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Overweight trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Overweight clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 485 trials

Recruiting
Phase 2

Efficacy and Safety of Oral KAI-7535 in Adult Participants Living With Obesity or Overweight With at Least 1 Weight-Related Comorbidity

ObesityOverweight
Kailera320 enrolled23 locationsNCT07497880
Recruiting

Genetic, Microbiological and Behavioral Factors in Obesity

ObesityObesity, OverweightGenetics
Jan Kochanowski University200 enrolled2 locationsNCT07650149
Recruiting
Phase 1

A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body

ObesityHealthyOverweight
Boehringer Ingelheim80 enrolled1 locationNCT07407348
Recruiting
Not Applicable

Time Restricted Eating (TRE) in Bipolar Disorder

Bipolar Disorder DepressionBipolar Disorder (BD)Overweight (BMI > 30)
Massachusetts General Hospital40 enrolled1 locationNCT07211217
Recruiting
Not Applicable

DASH-Obesity: Explainable AI for Family-Centric Personalized Weight Control in Adolescents and Young Adults With Obesity and Chronic Conditions

Obesity, OverweightAsthma (Diagnosis)Type 1 Diabetes+3 more
Adhera Health, Inc.280 enrolled1 locationNCT07638345
Recruiting
Phase 1

A Study to Evaluate the Safety and Tolerability of Different Doses of CX11 Tablets

Obesity, Overweight
Corxel Pharmaceuticals90 enrolled2 locationsNCT07652047
Recruiting

Real-World Case Registry Study on Obesity

Obesity, OverweightObesity (Disorder)
Hubei Hospital of Traditional Chinese Medicine10,000 enrolled1 locationNCT07448090
Recruiting
Not Applicable

Efficacy of Center-based Childcare to Mitigate Unhealthy Weight Gain in Preschoolers From Low-income Households During the Summer

Obesity, Overweight
University of South Carolina300 enrolled1 locationNCT07583459
Recruiting
Phase 3

Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity

Obesity and Overweight
Pfizer3,501 enrolled170 locationsNCT07311850
Recruiting
Phase 3

Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)

Obesity or Overweight
Amgen300 enrolled40 locationsNCT07575399
Recruiting
Phase 1Phase 2

A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM

Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled22 locationsNCT06845202
Recruiting
Phase 4

A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

Psoriatic ArthritisOverweight or Obesity
Eli Lilly and Company200 enrolled55 locationsNCT06864026
Recruiting
Phase 2

A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)

ObesityBody WeightOverweight+5 more
Pfizer872 enrolled48 locationsNCT07575932
Recruiting
Not Applicable

Identification of Pre-surgical Phenotypic Indicators Predictive of Quality of Life Trajectories in Obese Patients Following Bariatric Surgery

Obesity and OverweightBariatric SurgeryObesity, Morbid+4 more
Centre Hospitalier Metropole Savoie165 enrolled1 locationNCT06951893
Recruiting
Not Applicable

Long-term Adaptations of Skeletal Muscle After Hybrid Training

Obesity, Overweight
University of Thessaly30 enrolled1 locationNCT07341711
Recruiting
Phase 3

AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

ObesityOverweightObstructive Sleep apnoea
Novo Nordisk A/S300 enrolled91 locationsNCT07571109
Recruiting
Not Applicable

Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy

Obesity, OverweightDehydrationType 2 Diabetes+2 more
State University of New York at Buffalo30 enrolled1 locationNCT07641361
Recruiting
Phase 3

Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes

Obesity With DiabetesOverweight With Diabetes
Kailera1,700 enrolled52 locationsNCT07284901
Recruiting
Phase 3

Efficacy and Safety of KAI-9531 in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes

ObesityOverweight
Kailera1,800 enrolled37 locationsNCT07284875
Recruiting
Phase 2

Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)

Healthy VolunteersOverweight
National Institute on Alcohol Abuse and Alcoholism (NIAAA)150 enrolled1 locationNCT03407079