Overweight Clinical Trials

489 recruitingLast updated: June 19, 2026

There are 489 actively recruiting overweight clinical trials across 58 countries. Studies span Not Applicable, Phase 1, Phase 3, Phase 2, Phase 4, Early Phase 1. Top locations include Houston, Texas, United States, Dallas, Texas, United States, San Antonio, Texas, United States. Updated daily from ClinicalTrials.gov.


Overweight Trials at a Glance

489 actively recruiting trials for overweight are listed on ClinicalTrialsFinder across 6 cities in 58 countries. The largest study group is Not Applicable with 255 trials, with the heaviest enrollment activity in Houston, Dallas, and San Antonio. Lead sponsors running overweight studies include Eli Lilly and Company, Novo Nordisk A/S, and Johns Hopkins University.

Browse overweight trials by phase

Treatments under study

About Overweight Clinical Trials

Looking for clinical trials for Overweight? There are currently 188 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Overweight trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Overweight clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 489 trials

Recruiting
Phase 2

Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)

Healthy VolunteersOverweight
National Institute on Alcohol Abuse and Alcoholism (NIAAA)150 enrolled1 locationNCT03407079
Recruiting
Phase 3

A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

ObesityOverweight
Eli Lilly and Company125 enrolled50 locationsNCT06672549
Recruiting
Phase 3

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

ObesityOverweightAtherosclerotic Cardiovascular Disease
Amgen12,800 enrolled774 locationsNCT07037433
Recruiting
Phase 2

A Trial to Evaluate Efficacy and Safety of Maridebart Cafraglutide in Adults Living With Elevated Liver Fat and Obesity or Overweight

Overweight or Obesity and Elevated Liver Fat
Amgen180 enrolled23 locationsNCT07441252
Recruiting
Phase 3

A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities

ObesityOverweight
Eli Lilly and Company150 enrolled40 locationsNCT06672939
Recruiting
Phase 3

Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes

Obesity With DiabetesOverweight With Diabetes
Kailera1,700 enrolled58 locationsNCT07284901
Recruiting
Phase 3

Efficacy and Safety of KAI-9531 in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes

ObesityOverweight
Kailera1,800 enrolled44 locationsNCT07284875
Recruiting

Genetic, Microbiological and Behavioral Factors in Obesity

ObesityObesity, OverweightGenetics
Jan Kochanowski University200 enrolled2 locationsNCT07650149
Recruiting
Not Applicable

Brief Inhibitory Training for Eating - Intervention

Overweight and/or Obesity
George Mason University36 enrolled1 locationNCT07592728
Recruiting
Phase 2

Efficacy and Safety of Oral KAI-7535 in Adult Participants Living With Obesity or Overweight With at Least 1 Weight-Related Comorbidity

ObesityOverweight
Kailera320 enrolled23 locationsNCT07497880
Recruiting
Not Applicable

SucroMet Nutritional Intervention Trial

Glucose metabolismOverweight/Obesity
Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud120 enrolled1 locationNCT07656298
Recruiting
Not Applicable

Effect of the Thrive AI Health App on Lifestyle Behaviors and Quality of Life

Diabetes Type 2Overweight or Obesity
Yale University20 enrolled1 locationNCT07376655
Recruiting
Phase 1

A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body

ObesityHealthyOverweight
Boehringer Ingelheim80 enrolled1 locationNCT07407348
Recruiting
Phase 1

A Study to Evaluate the Safety and Tolerability of Different Doses of CX11 Tablets

Obesity, Overweight
Corxel Pharmaceuticals90 enrolled2 locationsNCT07652047
Recruiting
Not Applicable

DASH-Obesity: Explainable AI for Family-Centric Personalized Weight Control in Adolescents and Young Adults With Obesity and Chronic Conditions

Obesity, OverweightAsthma (Diagnosis)Type 1 Diabetes+3 more
Adhera Health, Inc.280 enrolled1 locationNCT07638345
Recruiting
Not Applicable

Time Restricted Eating (TRE) in Bipolar Disorder

Bipolar Disorder DepressionBipolar Disorder (BD)Overweight (BMI > 30)
Massachusetts General Hospital40 enrolled1 locationNCT07211217
Recruiting

Validity and Reliability of Mixed Reality-Based Performance Tests in Overweight and Obese Adults

Overweight and Obesity
Selcuk University119 enrolled1 locationNCT07654439
Recruiting
Phase 3

Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)

Obesity or Overweight
Amgen300 enrolled40 locationsNCT07575399
Recruiting

Real-World Case Registry Study on Obesity

Obesity, OverweightObesity (Disorder)
Hubei Hospital of Traditional Chinese Medicine10,000 enrolled1 locationNCT07448090
Recruiting
Phase 1Phase 2

A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM

Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled22 locationsNCT06845202