RecruitingNot ApplicableNCT05334979

Oxalate and Citrate

Oxalate and Citrate in Humans

Sponsor

University of Chicago

Enrollment

50 participants

Start Date

Oct 27, 2022

Study Type

INTERVENTIONAL

Conditions

Kidney Stone Normal Controls

Summary

This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria7

Stone formers:
Age 18-70
History of at least one calcium-based kidney stone
Non-stone formers (controls):
Age 18-70
No history of kidney stone
hour urine oxalate within lab normal (\<50mg/day)

Exclusion Criteria4

History of primarily uric acid, cysteine, or struvite stones.
History of severe acid-base abnormality, very low (less than 100mg/day) or very high (greater than 1500mg/day) urine citrate.
Any controls or stone-forming participants who cannot stop diuretic medication or alkali supplementation for the course of the study period.
Non-stone formers and stone-formers with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.

Print for Your Doctor

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

OTHERKidney stones Normal controls Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic

Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic Subjects in both arms will be asked to partake in the same activities, as follows: The day before presenting to the research clinic subjects will collect urine at home. Subjects will will come in to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. We will give them a special liquid that contains oxalate, and they will receive a specially prepared breakfast that is low in oxalate and citrate. After this, we will collect urine and blood throughout the day. While at the clinic, subjects will also receive specially prepared snacks.