RecruitingNot ApplicableNCT05334979

Oxalate and Citrate

Oxalate and Citrate in Humans

Sponsor

University of Chicago

Enrollment

50 participants

Start Date

Oct 27, 2022

Study Type

INTERVENTIONAL

Conditions

Kidney Stone Normal Controls

Summary

This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study investigates how oxalate (a compound found in many foods) and citrate (a natural inhibitor of kidney stones) interact in the urine of kidney stone formers versus people who have never had stones. The goal is to better understand what drives calcium-based kidney stone formation. You may be eligible if: - You are between 18 and 70 years old - You have a history of at least one calcium-based kidney stone (stone formers group), OR you have never had a kidney stone and your urine oxalate is within normal limits (control group) You may NOT be eligible if: - Your stones were primarily uric acid, cysteine, or struvite (not calcium-based) - You have a history of severe acid-base abnormalities, or very low or very high urine citrate levels - You cannot stop taking diuretics or alkali supplements during the study period Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERKidney stones Normal controls Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic

Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic Subjects in both arms will be asked to partake in the same activities, as follows: The day before presenting to the research clinic subjects will collect urine at home. Subjects will will come in to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. We will give them a special liquid that contains oxalate, and they will receive a specially prepared breakfast that is low in oxalate and citrate. After this, we will collect urine and blood throughout the day. While at the clinic, subjects will also receive specially prepared snacks.

Locations(1)

University of Chicago Medical Center

Chicago, Illinois, United States

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NCT05334979

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