Performances on Cognitive Functions and Brain Function and Follow-up After Different Treatments in Patients With Autonomous Cortisol Secretion: a Single-center, Prospective, Observational Study
A Single Center, Prospective, Observational Study to Explore and Evaluate the Differences of Cognitive Function and Brain Function Between Non-functioning Adrenal Adenomas and Autonomous Cortisol Secretion Patients, and the Different Treatments Methods on Cognitive Function and Brain Function in Patients With Autonomous Cortisol Secretion
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
62 participants
Oct 1, 2021
OBSERVATIONAL
Conditions
Summary
This is a single center, prospective, observational study to explore and evaluate the differences on cognitive function and brain function by functional-MRI in autonomous cortisol secretion patients, and the different treatments methods on the cognitive function and brain function in patients with autonomous cortisol secretion
Eligibility
Inclusion Criteria7
- age 20-65 years;
- ≥ 6 years of education；
- right-handed;
- complete entire cognitive function tests;
- adrenal lesions ≥ 1 cm in diameter;
- patients with non-functioning adrenal adenomas;
- patients with autonomous cortisol secretion.
Exclusion Criteria18
- \< 6 years of education;
- age \< 20 years or \> 65 years;
- maximum diameter of AI \<1cm;
- active malignancies;
- with a history of thyroid disease;
- with a history of acute infection in the last month;
- central nervous system diseases, including brain trauma, intracranial hemorrhage, acute cerebral infarction, etc;
- contraindications of MRI examination: such as implantation of metal prosthesis in vivo, claustrophobia, etc;
- adrenal tuberculosis;
- suspected or diagnosed adrenocortical carcinoma;
- unable to complete entire cognitive function tests;
- current use of steroids or any drugs known to alter steroid synthesis or metabolism in the previous 3 months;
- clinical Cushing syndrome;
- Cushing disease;
- primary hyperaldosteronism;
- pheochromocytoma;
- severe impairment of heart, liver, kidney and other organs;
- pregnant and lactating women
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Interventions
cognitive function measurement
Only a subgroup of the autonomous cortisol secretion patients will have the laparoscopic adrenal surgery
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05357456