Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion
Qifu Li
521 participants
Jan 2, 2025
OBSERVATIONAL
Conditions
Summary
To evaluate the incidence of adrenal insufficiency after surgery in Primary aldosteronism (PA) patients concurrent with or without autonomous cortisol secretion (ACS). To assess the recovery time of postoperative adrenal insufficiency in patients. And to explore the clinical characteristics and predictive indicators of patients requiring postoperative hormone replacement therapy.
Eligibility
Inclusion Criteria2
- A confirmed diagnosis of primary aldosteronism or autonomous cortisol secretion;
- ② Completion of unilateral adrenal surgery;
Exclusion Criteria5
- Patients with typical clinical manifestations of Cushing's syndrome;
- Patients suspected of having bilateral cortisol over-secretion, such as PBMAH or PPNAD; ③ Patients with severe surgical complications, unstable postoperative condition (not due to cortical insufficiency), and difficulty completing the ACTH stimulation test;
- History of ACTH allergy;
- Patients requiring long-term hormone therapy for other diseases (such as autoimmune diseases);
- Severe liver and kidney dysfunction (ALT ≥ 3 times the upper limit of normal; patients undergoing dialysis or with an estimated glomerular filtration rate < 30 ml/min/m2); ⑦ History of contralateral adrenal surgery; ⑧ Patients with poor compliance who are unable to complete the study.
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Interventions
patients complete ACTH stimulation test on the one day after surgery and complete ACTH stimulation test 1 or 4 week for patients with Adrenal Insufficiency
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06955286