RecruitingPhase 3NCT05358535

Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)


Sponsor

University of Texas Southwestern Medical Center

Enrollment

200 participants

Start Date

Sep 19, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to evaluate the hemodynamics and adverse event profile in comparison between two treatment arms, one using an admixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7), and one using an admixture of propofol and etomidate at a ratio by volume of 75%/25% (P7E2), for anesthesia during endoscopic procedures at the Clements University Hospital (CUH) endoscopy lab (Endo).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study (PEAC Trial) is comparing two anesthetic drug mixtures — propofol combined with etomidate in different ratios — to determine which provides the best balance of safety and effectiveness for patients undergoing endoscopic procedures (such as colonoscopy) who are higher-risk due to their medical status. You may be eligible if... - You are 18 or older - You are having an endoscopic procedure at the hospital with anesthesia - You have an ASA classification of 3 or above (indicating moderate or severe medical conditions) - Your ejection fraction test results are available You may NOT be eligible if... - You have a known allergy or adverse reaction to the study drugs - You or your clinician refuse participation - You have a documented cognitive impairment and no legal decision-maker to consent on your behalf - You are a prisoner - You are pregnant or refuse pregnancy testing before anesthesia Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGAdmixture of propofol and etomidate at a ratio by volume of 75%/25% (P7E2)

The purpose of this study is to evaluate the hemodynamics and adverse event profile in comparison between two treatment arms, one using an admixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7), and one using an admixture of propofol and etomidate at a ratio by volume of 75%/25% (P7E2), for anesthesia during endoscopic procedures at the Clements University Hospital (CUH) endoscopy lab (Endo). The objectives are to compare the treatment arms, P2E7 and P7E2, in a randomized controlled double-blind trial for anesthesia for endoscopic procedures. Comparison between an admixture of Propofol/Etomidate 75%/25% versus 25%/75% being utilized as principal anesthetic for endoscopic procedures at CUH endoscopy lab.

DRUGAdmixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7)

The purpose of this study is to evaluate the hemodynamics and adverse event profile in comparison between two treatment arms, one using an admixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7), and one using an admixture of propofol and etomidate at a ratio by volume of 75%/25% (P7E2), for anesthesia during endoscopic procedures at the Clements University Hospital (CUH) endoscopy lab (Endo). The objectives are to compare the treatment arms, P2E7 and P7E2, in a randomized controlled double-blind trial for anesthesia for endoscopic procedures. Comparison between an admixture of Propofol/Etomidate 75%/25% versus 25%/75% being utilized as principal anesthetic for endoscopic procedures at CUH endoscopy lab.


Locations(1)

Clements University Hospital

Dallas, Texas, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05358535


Related Trials