RecruitingNCT05364749

Selective CT for Anticoagulated Head Injured Patients

Selective Neuroimaging for Head-injured Emergency Patients Who Take Anticoagulant Medication


Sponsor

Dr. Kerstin de Wit

Enrollment

4,000 participants

Start Date

Mar 17, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

The goal is to derive and a clinical decision rule for safe exclusion of traumatic brain injury without neuroimaging in head-injured ED patients who take anticoagulant medications. The objectives are to: 1. Derive and externally validate a new highly sensitive and maximally specific clinical decision rule for the exclusion of traumatic brain injury in head-injured ED patients who take anticoagulant medications; and, 2. Estimate the sensitivity and specificity of existing head injury clinical decision rules in head-injured ED patients who take anticoagulant medications.


Eligibility

Min Age: 16 Years

Inclusion Criteria4

  • Age ≥16 years
  • Presents to the emergency department after a head injury
  • Patient has a head CT in the emergency department
  • Is a current anticoagulant user

Exclusion Criteria7

  • Head injury occurred \>48 h before patient's arrival to the emergency department
  • Penetrating head injury
  • Previously enrolled
  • Patient resides outside of the hospital's catchment area
  • Patient was transferred from another emergency department following neuroimaging
  • Patient was not managed by the emergency or trauma physician in the emergency department
  • Leaves the emergency department prior to completion of their medical assessment

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Locations(7)

University of British Columbia

Vancouver, British Columbia, Canada

Hamilton Health Sciences Corporation

Hamilton, Ontario, Canada

Kingston Health Sciences Centre

Kingston, Ontario, Canada

Ottawa Hospital Research Institute

Ottawa, Ontario, Canada

Sinai Health

Toronto, Ontario, Canada

Hôpital du Sacré-Cœur de Montréal

Montreal, Quebec, Canada

CHU de Québec - Université Laval

Québec, Quebec, Canada

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NCT05364749


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