RecruitingNCT05372159

Vanderbilt Memory and Aging Project

Sponsor

Vanderbilt University Medical Center

Enrollment

1,000 participants

Start Date

Sep 17, 2012

Study Type

OBSERVATIONAL

Conditions

Cognitive Dysfunction Biomarkers Alzheimer Disease Aging Brain Aged, 80 and Over Case-Control Studies Neuropsychological Tests

Summary

This study will use an observational cohort to cross-sectionally and longitudinally relate vascular health to clinical, imaging, and biological markers of early Alzheimer's disease and cerebrovascular disease among aging adults. Adjusting for relevant clinical covariates, we will test the hypothesis that vascular health is associated with clinical, brain magnetic resonance imaging (MRI), neuropsychological, and cerebrospinal fluid markers of early cerebrovascular and Alzheimer's disease changes (i.e., prior to the onset of significant cognitive decline or dementia). Secondarily, we will examine medical and genetic factors that might mediate associations between vascular health and brain aging, such as inflammatory processes, insulin resistance, and genetic factors (e.g., APOE, a susceptibility risk factor for dementia). Findings will advance knowledge regarding the role that vascular health plays in brain aging.

Eligibility

Min Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This is the Vanderbilt Memory and Aging Project, a long-term study following adults aged 50 and older to understand how heart health, lifestyle, and aging affect memory and brain function over time. Researchers will use brain scans, blood tests, and memory assessments to track cognitive changes. **You may be eligible if...** - You are 50 years or older - You have normal cognition OR have been diagnosed with mild cognitive impairment (early memory problems that don't affect daily function) - English is your primary language - You have a study partner available (a friend or family member who can help with assessments) **You may NOT be eligible if...** - You have been diagnosed with Alzheimer's disease, stroke, Parkinson's disease, epilepsy, or another neurological condition - You have a history of serious psychiatric illness (schizophrenia, bipolar disorder) - You have been diagnosed with congestive heart failure, atrial fibrillation, COPD, or current cancer - You have a history of significant alcohol or drug abuse - You cannot have an MRI (due to a pacemaker, certain metal implants, or pregnancy) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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