A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure on TLD in Sub-Saharan Africa

This study is testing different treatment strategies for people with HIV in sub-Saharan Africa whose virus is no longer being suppressed by their current medication regimen (called TLD — tenofovir, lamivudine, and dolutegravir). Researchers want to find the best next treatment when TLD stops working. **You may be eligible if...** - You are 15 or older - You are receiving HIV care at one of the study clinics - You have had two HIV viral load measurements above 1,000 copies/mL while on TLD treatment - You have been on TLD for at least 12 months - You live within 100 km of the study clinic - Pregnant women are eligible to participate **You may NOT be eligible if...** - You plan to transfer to a different clinic or move out of the study area within the next 48 weeks - You have previously had HIV treatment failure on protease inhibitor drugs or have been treated with integrase inhibitors other than dolutegravir Talk to your doctor to see if this trial is right for you.