First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia

This study is testing a new type of brain scan — a PET scan using a specially designed tracer — to help detect early signs of dementia by looking at how well certain brain cells (called astrocytes) are working. It's the first time this specific tracer is being tested in humans. **You may be eligible if...** - You are between 40 and 75 years old - You are a non-smoker and not using nicotine replacement products - You have not taken prescription brain/nervous system medications for at least 3 weeks - You are generally healthy with no major physical disorders - For some groups: you have a study partner (family member or close friend) who can share observations about your daily life and memory **You may NOT be eligible if...** - You are a current smoker - You are on certain prescription medications that affect the brain - You do not have suitable arm arteries for a blood draw procedure Talk to your doctor to see if this trial is right for you.