Frontotemporal Dementia Clinical Trials

39 recruitingLast updated: June 18, 2026

There are 39 actively recruiting frontotemporal dementia clinical trials across 17 countries. Studies span Not Applicable, Phase 2, Phase 1, Early Phase 1, Phase 4. Top locations include Toronto, Ontario, Canada, London, Ontario, Canada, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Frontotemporal Dementia Trials at a Glance

39 actively recruiting trials for frontotemporal dementia are listed on ClinicalTrialsFinder across 6 cities in 17 countries. The largest study group is Not Applicable with 10 trials, with the heaviest enrollment activity in Toronto, London, and New York. Lead sponsors running frontotemporal dementia studies include University Health Network, Toronto, University Hospital, Lille, and Alfred Health.

Browse frontotemporal dementia trials by phase

Treatments under study

About Frontotemporal Dementia Clinical Trials

Looking for clinical trials for Frontotemporal Dementia? There are currently 25 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Frontotemporal Dementia trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Frontotemporal Dementia clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 39 trials

Recruiting

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Amyotrophic Lateral SclerosisFrontotemporal DementiaProgressive Supranuclear Palsy
National Institute of Neurological Disorders and Stroke (NINDS)360 enrolled1 locationNCT03225144
Recruiting

Clinical Procedures to Support Research in ALS

Amyotrophic Lateral SclerosisPrimary Lateral SclerosisProgressive Muscular Atrophy+1 more
University of Miami1,200 enrolled11 locationsNCT03489278
Recruiting
Not Applicable

GENetic Fronto Temporal Dementia Initiative in Lille

Frontotemporal Dementia
University Hospital, Lille20 enrolled1 locationNCT04639622
Recruiting

Tanycytes in Alzheimer's Disease and Frontotemporal Dementia

Alzheimer DiseaseFrontotemporal Dementia
University Hospital, Lille102 enrolled1 locationNCT05288842
Recruiting
Not Applicable

Retinal Hyperspectral Imaging in Neurodegenerative Diseases

DementiaAlzheimer DiseaseParkinson Disease+5 more
Center for Eye Research Australia930 enrolled1 locationNCT07545473
Recruiting

Links Between Self-awareness and Sociocognitive Processes in Neurodegenerative Diseases

Alzheimer DiseaseFrontotemporal Dementia, Behavioral Variant
Assistance Publique - Hôpitaux de Paris34 enrolled1 locationNCT07531732
Recruiting
Phase 1Phase 2

A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)

Frontotemporal DementiaFTDDementia, Frontotemporal+1 more
AviadoBio Ltd18 enrolled19 locationsNCT06064890
Recruiting
Not Applicable

Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders

PSP - Progressive Supranuclear PalsyAlzheimer Dementia (AD)MSA - Multiple System Atrophy+7 more
Universitaire Ziekenhuizen KU Leuven300 enrolled1 locationNCT07509125
Recruiting
Not Applicable

Transcranial Alternating Current Stimulation in Frontotemporal Dementia

Frontotemporal Dementia (FTD)Transcranial Alternating Current Stimulation
IRCCS Centro San Giovanni di Dio Fatebenefratelli30 enrolled1 locationNCT07505784
Recruiting

Disease Biosignatures in ALS/FTD Spectrum: New Impactful Biological Perspectives Beyond Clinical Approaches

FTDALS (Amyotrophic Lateral Sclerosis)Frontotemporal Dementia (FTD)+3 more
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta230 enrolled4 locationsNCT06856850
Recruiting
Phase 2

Vortioxetine for the Treatment of Mood and Cognitive Symptoms in Frontotemporal Dementia

fronto-temporal dementiaFrontotemporal DementiaFrontotemporal Degeneration+3 more
Johns Hopkins University50 enrolled1 locationNCT06604520
Recruiting

Retinal Imaging in Neurodegenerative Disease

Traumatic Brain InjuryHuntington DiseaseNeuro-Degenerative Disease+12 more
Duke University2,000 enrolled1 locationNCT03233646
Recruiting

Comprehensive Assessment of Neurodegeneration and Dementia

DementiaMild Cognitive Impairment (MCI)Subjective Cognitive Impairment+7 more
McGill University1,573 enrolled19 locationsNCT03402919
Recruiting
Phase 1Phase 2

A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes

Frontotemporal DementiaFTDDementia, Frontotemporal+2 more
Passage Bio, Inc.30 enrolled10 locationsNCT04747431
Recruiting

Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling

DementiaAlzheimer DiseaseParkinson Disease+7 more
University Health Network, Toronto500 enrolled4 locationsNCT06529744
Recruiting
Not Applicable

STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners

Caregiver BurdenCorticobasal SyndromePrimary Progressive Aphasia(PPA)+1 more
Oregon Health and Science University640 enrolled1 locationNCT06613204
Recruiting
Not Applicable

Non-invasive Neurostimulation as a Tool for Diagnostics and Management for Neurodegenerative Diseases

Alzheimer DiseaseDementia With Lewy BodiesFrontotemporal Dementia
Kuopio University Hospital200 enrolled1 locationNCT05326750
Recruiting
Not Applicable

Using the EHR to Advance Genomic Medicine Across a Diverse Health System

ParagangliomaPheochromocytomaGenetic Predisposition+7 more
University of Pennsylvania1,000 enrolled1 locationNCT06377033
Recruiting

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

Amyotrophic Lateral SclerosisCorticobasal Degeneration (CBD)Progressive Supranuclear Palsy (PSP)+11 more
Mayo Clinic2,100 enrolled27 locationsNCT04363684
Recruiting

Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)

Frontotemporal DementiaMyopathyInclusion Body Myopathy With Early-onset Paget Disease and Frontotemporal Dementia+1 more
University of California, Irvine50 enrolled1 locationNCT01353430