RecruitingNot ApplicableNCT05377125

Neural Mechanisms of Response Inhibition Training for OCRD

Neural Mechanisms of Response Inhibition Training for Obsessive-Compulsive Disorder and Related Conditions

Sponsor

University of Wisconsin, Milwaukee

Enrollment

118 participants

Start Date

Dec 22, 2022

Study Type

INTERVENTIONAL

Conditions

Obsessive-Compulsive Disorder Tricholemmoma Skin-Picking

Summary

The impaired ability to suppress an inappropriate but pre-potent response (response inhibition; RI) characterizes several debilitating clinical problems, including obsessive-compulsive and related disorders (OCRD) such as obsessive-compulsive disorder, trichotillomania, and skin picking disorder. There is a critical need to develop an effective and durable treatment for OCRDs with demonstrable evidence for improving impaired RI. The purpose of our project is to examine the impact of a novel computerized intervention, response inhibition training (RIT), on neural indices of RI, and examine the mechanistic link between engagement of the neural RI targets and change in OCRD symptoms. To this end, this project will conduct a randomized clinical trial for individuals with OCD, trichotillomania, and/or skin picking disorders. Participants will be randomly assigned to 8 to 16 sessions of computerized RIT or a computerized placebo training. Various clinical, behavioral, and brain-imaging data will be acquired to evaluate the training effects at baseline, post-training, and 1-month follow-up periods.

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how brain training exercises that help with impulse control (called response inhibition training) work in people with obsessive-compulsive related disorders (OCRDs) — such as OCD, hair-pulling disorder (trichotillomania), or skin-picking disorder. **You may be eligible if...** - You are between 18 and 60 years old - You have been diagnosed with OCD, trichotillomania (hair pulling), or skin picking disorder as your primary condition - Your symptoms are at a moderate level or above (assessed by standard questionnaires) - Your estimated IQ is above 80 - You show measurable deficits in impulse control on testing **You may NOT be eligible if...** - You currently have a substance use disorder - You have severe ADHD or a history of psychosis, bipolar disorder, or schizophrenia - You are currently in psychotherapy or have recently changed your psychiatric medication - You are currently at risk for suicide or have MRI contraindications Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALComputerized cognitive training

This intervention offers 45-minute computerized training sessions to each participant. This intervention aims to improve the individual's RI capabilities. All participants will receive 8 to 16 sessions after being randomized to this condition.

BEHAVIORALComputerized placebo training

This intervention offers 45-minute computerized placebo cognitive training sessions to each participant. This intervention aims to exert no focused training on RI capabilities. All participants will receive 8 to 16 sessions after being randomized to this condition.