RecruitingNot ApplicableNCT05378841

Efficacy of Surgical Joint Denervation in Painful Digital Osteoarthritis

Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

19 participants

Start Date

Jun 5, 2023

Study Type

INTERVENTIONAL

Conditions

Osteoarthritis Hand

Summary

Digital osteoarthritis is the second localization of symptomatic osteoarthritis, after the knee. Its cardinal symptoms are particularly intense pain and functional impairment in the case of the erosive form. There is currently no etiological treatment for osteoarthritis. Symptomatic treatments have a modest efficacy, which justifies the search for new treatments. The surgical options are arthrodesis or prosthesis, invasive techniques potentially sources of complications, and finally proposed infrequently given the prevalence of digital osteoarthritis. DECAD is a prospective phase II trial aimed at evaluating the efficacy of surgical joint denervation in painful digital osteoarthritis.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a surgical procedure called joint denervation — cutting the nerves that transmit pain from a specific finger joint — can relieve chronic pain in people with digital (finger) osteoarthritis who have not responded to medications or other treatments. You may be eligible if... - You are 18 years or older - You have symptomatic finger osteoarthritis affecting at least one PIP (middle) joint - Your pain is 4 or above out of 10 and has lasted more than 3 months - You have already tried standard treatments (analgesics, NSAIDs, injections) for at least 3 months without sufficient relief - You can read French (for questionnaires) You may NOT be eligible if... - Your finger OA is caused by another condition (e.g., gout, rheumatoid arthritis, psoriatic arthritis) - You have contraindications to surgery or MRI - You have fibromyalgia or another pain syndrome in the upper limbs - You have recently received corticosteroids or immunosuppressant medications - You have previously had denervation of the same joint Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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