Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis
Low-Dose Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis
Mayo Clinic
165 participants
Dec 19, 2025
INTERVENTIONAL
Conditions
Summary
The purpose of this research is to compare low-dose radiotherapy to corticosteroid injection for treatment of hand/wrist osteoarthritis.
Eligibility
Inclusion Criteria5
- Patient at Mayo Clinic, Rochester, MN
- Age 50 years or older
- Mild, moderate, or severe hand OA (Kellgren and Lawrence classification grade 2, 3, or 4) on hand radiographs within the last 24 months
- Hand OA pain with a minimum VAS score relating to hand pain of ≥40 (on a 100-point scale) when using the affected hand
- Ability to complete study questionnaires
Exclusion Criteria12
- History of previous surgery to the affected hand(s)
- Autoimmune joint disease such as rheumatoid arthritis or psoriatic arthritis
- Active confounding hand condition such as stenosing tenosynovitis or Dupuytren's contracture
- Recent injury (within last 1 month) to the affected hand causing current pain
- History of crystalline arthritis (gout or pseudogout) flare in the affected hand(s)
- Active use of opioid pain medication(s) or oral steroids within the last 3 months
- Fibromyalgia or central sensitization syndrome
- Hand CSI or other hand injection within the past 3 months
- History of hand LDRT within the past 3 months
- Poorly controlled diabetes (HbA1c \> 10%)
- Active infection
- Current pregnancy
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Interventions
A maximum of 3 joints will be treated with standard a standard combination of methylprednisolone and lidocaine: * 1st Carpometacarpal (CMC) joint - 20 mg methylprednisolone/0.5 mL 1% lidocaine\* * Radiocarpal (RC) joint - 40 mg methylprednisolone/1 mL 1% lidocaine\* * Scaphotrapeziotrapezoidal (STT) joint - 20 mg methylprednisolone/0.5 mL 1% lidocaine\* * Metacarpophalangeal (MCP) joint - 20 mg methylprednisolone/0.5 mL 1% lidocaine * Interphalangeal (IP) joint - 10 mg methylprednisolone/0.25 mL 1% lidocaine
Subjects will be treated with low-dose radiotherapy of 300cGy in 6 fractions, 2-3 times per week on non-consecutive days. Non-responders to the initial LDRT treatment will receive a second treatment course of 300cGy in 6 fractions to be given 2-3 times per week on non-consecutive days.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07217405